Member Spotlight: Gianni Sesa-Ashton

Member Spotlight: Gianni Sesa-Ashton

Gianni Sesa-Ashton is a final-year medical student at the Baker Heart and Diabetes Institute and Head of Strategy and Communications at Hypertension Australia, with a strong focus on resistant hypertension and the role of the sympathetic nervous system in blood pressure regulation. His work spans renal denervation, innovative research techniques, and national screening initiatives, all aimed at improving outcomes for patients with complex hypertension.

What inspired your interest in Hypertension?

I’d always been interested in acute stress and cardiovascular disease – my grandmother had takotsubo cardiomyopathy (better known as broken heart syndrome) so that was a significant influence. I properly fell down the hypertension rabbit hole though during my undergraduate degree. I took a cardiovascular physiology unit in my third year and got exposed to the epidemiology and complex pathophysiology of the condition. The idea that something affected so many people, had such significant clinical consequences, and how all of the pieces of the physiology connected were still being worked out really opened my eyes. The sympathetic component of blood pressure regulation stuck with me and I ended up doing my Honours looking at how the prefrontal cortex can control sympathetic outflow and blood pressure in humans. I’ve been in clinical hypertension research ever since.

Tell us about your research or initiatives focused on preventing, detecting, and managing high blood pressure and its complications.

My research focus centres around the pathophysiology and treatment of resistant hypertension – patients who despite having more than three drug classes still have elevated blood pressure. I am a microneurographer by training, performing and interpreting direct nerve recordings of sympathetic fibres in humans to better understand sympathetic control of blood pressure in this cohort. Much of my work has been in renal denervation – the ablation of the renal nerves to reduce blood pressure in patients with treatment-resistant or complex to manage hypertension. My work has focussed on the long-term outcomes of the procedure and shown the blood pressure lowering effect persists well beyond the clinical trial period with patients on less antihypertensive medications with no adverse consequences for the kidneys. However, I’ve been lucky enough to be involved in diverse areas of hypertension research including the microbiome, novel brain networks controlling blood pressure, and cardiovascular reflexes. I’ve also had the pleasure to lead blood pressure screenings with May Measurement Month across Victoria, work towards improved blood pressure screening as a National Hypertension Taskforce Working Group Member and now excitingly be serving as the Director for Strategy and Communications for Hypertension Australia.

Tackling sympathetic overdrive for better outcomes in hypertension

Have you received any awards, grants, or publications for your work related to Hypertension?

Awards

  • Best of Hypertension Paper Award: Clinical Research, American Heart Association (2024)
  • Professor Geoffrey Burnstock Award for Young Investigators (2022)

Publications

What do you enjoy doing in your free time?

I, like seemingly everyone else in Melbourne, am a really keen rock climber with the not so nice looking hands to prove it. I also grew up playing classical guitar which melded into playing bass at some point when I wasn’t looking too carefully.

Beyond that, I volunteer to teach first and second year medical students clinical skills and try to demystify some of the course content which is always a highlight of my week.

Do you have any travel adventures or bucket list destinations you're hoping to experience?

My family is from Italy and I have never been which I need to do before all the Italian I know disappears from my memory. I am also looking to do a celebratory trip to Shanghai and Mongolia to go scramble up some mountains once I finish off my medical degree at the end of this year.

What's the last great book you read, movie you saw, or show you watched?

I just reread Cat’s Cradle by Kurt Vonnegut which was just as stellar as I remembered. I also read Love Prodigal by Traci Brimhall which is a new personal favourite.

Where can we find out more about your work with Hypertension?